Patrick M Kochanek Selected Research

Exsanguination

4/2012	Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.
9/2009	Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats.
4/2009	Blood-brain barrier integrity in a rat model of emergency preservation and resuscitation.
4/2009	Bakken Lecture: the brain, the heart, and therapeutic hypothermia.
11/2008	Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation.
5/2008	Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation.
2/2008	Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs.
10/2007	Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome.
2/2007	Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial.
4/2006	Induction of profound hypothermia for emergency preservation and resuscitation allows intact survival after cardiac arrest resulting from prolonged lethal hemorrhage and trauma in dogs.

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Patrick M Kochanek Research Topics

Disease

159	Traumatic Brain Injuries (Traumatic Brain Injury) 08/2022 - 01/2002
68	Heart Arrest (Cardiac Arrest) 06/2022 - 01/2002
56	Hypothermia 02/2022 - 01/2002
49	Brain Injuries (Brain Injury) 01/2022 - 07/2002
18	Wounds and Injuries (Trauma) 01/2021 - 01/2002
15	Hemorrhagic Shock 10/2021 - 10/2002
14	Ischemia 02/2022 - 05/2002
14	Brain Edema (Cerebral Edema) 01/2022 - 09/2013
13	Inflammation (Inflammations) 10/2021 - 09/2004
12	Neurologic Manifestations (Neurological Manifestations) 01/2022 - 01/2002
12	Ventricular Fibrillation 01/2021 - 10/2004
12	Intracranial Hypertension 01/2019 - 07/2003
11	Critical Illness (Critically Ill) 10/2021 - 04/2012
11	Craniocerebral Trauma (Head Injury) 01/2019 - 01/2002
10	Exsanguination 04/2012 - 04/2006
9	Asphyxia (Suffocation) 01/2022 - 02/2003
8	Brain Ischemia (Cerebral Ischemia) 06/2022 - 09/2004
8	Hypoxia (Hypoxemia) 02/2022 - 01/2004
8	Neuroinflammatory Diseases 10/2021 - 03/2013
8	Hemorrhage 01/2021 - 04/2006
8	Coma (Comas) 11/2020 - 05/2003
7	Seizures (Absence Seizure) 08/2017 - 03/2004
7	Epilepsy (Aura) 04/2016 - 04/2006
5	Contusions 10/2021 - 10/2002
5	Edema (Dropsy) 01/2018 - 02/2014
4	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2019 - 02/2015
4	Nervous System Diseases (Neurological Disorders) 01/2019 - 02/2008
4	Shock 01/2018 - 06/2011
4	Drowning 05/2015 - 03/2009
4	Hyperoxia 02/2014 - 08/2009
3	Brain Diseases (Brain Disorder) 08/2022 - 01/2015
3	Gliosis 02/2022 - 10/2016
3	Infections 01/2022 - 01/2010
3	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 10/2021 - 01/2006
3	Hypoglycemia (Reactive Hypoglycemia) 01/2018 - 01/2010
3	Drug-Related Side Effects and Adverse Reactions 12/2016 - 04/2012
3	Out-of-Hospital Cardiac Arrest 12/2016 - 09/2007
3	Brain Contusion 11/2016 - 05/2002

Drug/Important Bio-Agent (IBA)

48	Biomarkers (Surrogate Marker)IBA 06/2022 - 07/2004
24	Pharmaceutical PreparationsIBA 01/2021 - 01/2002
19	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2002
13	Oxygen (Dioxygen)IBA 01/2022 - 02/2008
12	AntioxidantsIBA 01/2022 - 01/2002
11	Phosphopyruvate Hydratase (Enolase)IBA 01/2022 - 02/2002
11	salicylhydroxamic acid (SHAM)IBA 01/2019 - 05/2002
11	Adenosine (Adenocard)FDA LinkGeneric 01/2017 - 03/2004
10	CytokinesIBA 06/2022 - 03/2004
9	EnzymesIBA 08/2015 - 05/2003
9	Glucose (Dextrose)FDA LinkGeneric 11/2014 - 05/2002
8	Neuroprotective AgentsIBA 02/2022 - 05/2002
8	Ringer's LactateIBA 10/2021 - 12/2009
8	Isoflurane FDA LinkGeneric 01/2018 - 05/2002
7	Hemoglobins (Hemoglobin)IBA 01/2022 - 03/2011
7	Fentanyl (Sublimaze)FDA LinkGeneric 12/2019 - 04/2003
7	IceIBA 12/2018 - 08/2005
6	diazonaphthalenedisulfonic acid (NDS)IBA 01/2022 - 05/2003
6	CaspasesIBA 01/2020 - 07/2002
6	Glial Fibrillary Acidic ProteinIBA 01/2020 - 06/2013
6	Cardiolipins (Cardiolipin)IBA 01/2019 - 08/2007
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 05/2004
6	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 11/2015 - 03/2006
5	Interleukin-6 (Interleukin 6)IBA 01/2020 - 01/2003
5	Minocycline (Cyclops)FDA LinkGeneric 11/2019 - 09/2009
5	LipidsIBA 01/2019 - 04/2008
5	Myelin Basic ProteinIBA 01/2018 - 07/2005
5	Cytochromes c (Cytochrome c)IBA 07/2012 - 07/2005
4	Glutathione (Reduced Glutathione)IBA 01/2022 - 09/2004
4	ChemokinesIBA 10/2021 - 11/2007
4	Hypnotics and Sedatives (Sedatives)IBA 01/2019 - 04/2009
4	Adenosine Monophosphate (AMP)IBA 01/2019 - 07/2012
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2015 - 01/2003
3	Mannitol (Osmitrol)FDA LinkGeneric 01/2022 - 12/2009
3	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2022 - 09/2013
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2021 - 03/2004
3	InterleukinsIBA 10/2021 - 01/2014
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2021 - 03/2004
3	Glyburide (Glibenclamide)FDA LinkGeneric 01/2021 - 01/2018
3	Levetiracetam (Keppra)FDA LinkGeneric 01/2020 - 03/2016
3	NitritesIBA 12/2019 - 05/2013
3	Opioid Analgesics (Opioids)IBA 03/2019 - 05/2008
3	HMGB1 Protein (HMG1)IBA 01/2019 - 07/2012
3	Probenecid (Benemid)FDA LinkGeneric 01/2018 - 10/2016
3	polynitroxylated pegylated hemoglobinIBA 01/2017 - 03/2011
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2016 - 01/2003
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 10/2016 - 01/2008
3	SilverIBA 10/2016 - 06/2011
3	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 11/2015 - 12/2006

Therapy/Procedure

65	Therapeutics 01/2022 - 01/2003
54	Resuscitation 10/2021 - 10/2002
39	Induced Hypothermia 01/2022 - 02/2002
15	Critical Care (Surgical Intensive Care) 01/2021 - 01/2002
14	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2022 - 01/2002
10	Cardiopulmonary Resuscitation (CPR) 01/2021 - 04/2006
9	Decompressive Craniectomy 03/2020 - 01/2003
7	Precision Medicine 01/2021 - 03/2016
6	Rewarming 03/2021 - 04/2003
5	Anesthesia 09/2009 - 04/2003
4	Induced Heart Arrest (Cardioplegia) 01/2021 - 03/2005
4	Drug Therapy (Chemotherapy) 01/2019 - 04/2012
3	Artificial Respiration (Mechanical Ventilation) 01/2020 - 04/2003